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Acute overdosage in humans has not been reported. In patients with metastatic cancer treated with the maximally tolerated doses of Nolvadex side acute neurotoxicity manifested by tremor, hyperreflexia, unsteady gait and dizziness were observed. If you supposes that took too much of this medication look for immediate medical help and contact your doctor. Storage Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment. 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In patients with metastatic cancer treated with the maximally tolerated doses of Nolvadex side acute neurotoxicity manifested by tremor, hyperreflexia, unsteady gait and dizziness were observed. If you supposes that took too much of this medication look for immediate medical help and contact your doctor. Store at room temperature between 20-25 C (68-77 F). If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time. Side effects are not expected. If they change from minor to severe you should immediately inform your doctor about it. Side effects caused by Nolvadex are: hot flashes, nausea, vomiting, weight gain, abnormal menstrual periods. Nolvadex is a non-steroid anti-estrogen which competitively inhibits estrogen receptors in the target organs and tumors in them. Mechanism of its action is not completely investigated though it is known that a complex of Nolvadex with the receptor and cofactor appears and than it is transferred to the cell nucleus preventing hypertrophy of the cells which depend on regulation by estrogen. The effect of the medication can last several weeks after a single dose. Nolvadex is able to cause ovulation in women, stimulation production of gonadotropic hormones of hypophysis. In men with oligospermia it increases concentration of luteinizing hormone and follicle-stimulating hormone, testosterone and estrogen in the blood serum. Nolvadex is used to treat breast cancer in women and in men (especially after castration) and also when it has spread to other parts of the body, kidney cancer, melanomas and sarcomas of the soft tissues with estrogen receptors, cancer of the ovary. Take it exactly as recommended by your physician as the dosage depends on your condition. Long treatment (about 2 years) is advised. 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